Insulin-like growth factor-binding protein 1 and 7 concentrations are lower in obese pregnant women, women with gestational diabetes and their fetuses

M Lappas

Journal article

Insulin-like growth factor-binding protein 1 and 7 concentrations are lower in obese pregnant women, women with gestational diabetes and their fetuses

M Lappas

Journal of Perinatology | Published : 2015

DOI: 10.1038/jp.2014.144

Abstract

Objective:To determine the effect of pre-existing maternal obesity and gestational diabetes mellitus (GDM) on the circulating levels of insulin growth factor-binding protein (IGFBPs) in cord and maternal plasma.Study Design:IGFBP-1-7 levels were measured on maternal and cord plasma from women with normal glucose tolerance (NGT) (30 non-obese and 36 obese) and GDM (44 non-obese and 26 obese) at the time of term elective cesarean section.Result:Maternal plasma IGFBP-1, IGFBP-6 and IGFBP-rP1 concentrations were significantly lower in NGT obese compared with NGT non-obese women and in non-obese GDM women compared with non-obese NGT women. In cord plasma, IGFBP-1-3 and IGFBP-rP1 concentrations we..

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University of Melbourne Researchers

Martha Lappas Author

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Grants

Awarded by Diabetes Australia Research Trust

Funding Acknowledgements

I would like to gratefully acknowledge the assistance of the Clinical Research Midwives Gabrielle Fleming, Astrid Tiefholz, Lyndall Paolucci, Debra Jinks and Asha Ferguson, and the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their co-operation. Associate Professor Martha Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; Grant No. 1047025). The work described in this manuscript was funded by a project grant from the NHMRC (Grant No. 454310), Diabetes Australia Research Trust (DART) and the Medical Research Foundation for Women and Babies.